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KMID : 0043320100330081135
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Archives of Pharmacal Research
2010 Volume.33 No. 8 p.1135 ~ p.1141
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Cytotoxic 10-(indol-3-yl)-[13]cytochalasans from the fungus Chaetomium elatum ChE01
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Thohinung Santi
Kanokmedhakul Somdej
Kanokmedhakul Kwanjai
Kukongviriyapan Veerapol
Tusskorn Ornanong
Soytong Kasem
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Abstract
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Nine 10-(indol-3-yl)-[13]cytochalasans such as a new chaetoglobosin V (1); two new natural products, prochaetoglobosin III (2) and prochaetoglobosin IIIed (3); six known chaetoglobosins B-D (4?6), F (7), and G (8) and isochaetoglobosin D (9) in addition to two known sterols, 24(R)-5α,8α-epidioxyergosta-6?22-diene-3β-ol (10) and ergosterol (11), were isolated from the fungus Chaetomium elatum ChE01. The structures of these compounds were elucidated by spectroscopic methods. Compounds 1?9 showed cytotoxicity against the human breast cancer (IC50 2.54?21.29 μM) and cholangiocarcinoma cell lines (IC50 3.41?86.95 μM).
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KEYWORD
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Chaetomium, Chaetomium elatum, Chaetoglobosin, Cytotoxicity, Cholangiocarcinoma
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